Synthesis and characterization of acetyl curcumin-loaded core/shell liposome nanoparticles via an electrospray process for drug delivery, and theranostic applications

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Ankireddy Seshadri ReddyJongsung Kim

Abstract

Despite substantial advancements in divergent drug delivery systems (DDS), there is still room for novel and innovative nanoparticle-mediated drug delivery methodologies such as core/shell liposomes to deliver drugs in a kinetically controlled manner into the active site without any side effects. Herein, ((1E,6E)-3,5-dioxohepta-1,6-diene-1,7-diyl) bis (2-methoxy-4,1-phenylene) diacetate acetyl curcumin (AC)-loaded poly(lactic-co-glycolic acid) (PLGA) core/shell liposome nanoparticles (ACPCSLNPs) were prepared using an electron spray method under an applied electric field, which facilitated the uniform formation of nano-sized liposome nanoparticles (LNPs). Then, kinetically controlled and sustained drug release profiles were investigated using the as-prepared ACPCSLNPs. Moreover, the inner polymeric core could not only induce the generation of electrostatic interactions between the polymer and drug molecules but could also affect the prominent repulsions between the polar head groups of lipids and the nonpolar drug molecules. As a result, the sustained maximum release of the drug molecules (~48.5%) into the system was observed over a long period (~4 days). Furthermore, cell cytotoxicity studies were conducted in a human cervical...Continue Reading

Citations

May 20, 2020·Frontiers in Pharmacology·Adhimoolam KarthikeyanTaesun Min
Jan 12, 2021·Archives of Medical Research·Shareni JeyamoganRuqaiyyah Siddiqui
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Gloria María Pontes-QueroBlanca Vázquez-Lasa
Nov 13, 2020·Biotechnology Advances·Amaia Huguet-CasqueroJose Luis Pedraz
Jun 3, 2021·Gels·Bibi Noorheen Haleema Mooneerah NeerooaSin-Yeang Teow

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