Synthesis and Characterization of Anionic Triazine Dendrimers with a Labile Disulfide Core.

Israel Journal of Chemistry
W ZhangEric E Simanek

Abstract

Anionic dendrimers based on melamine with disulfide bonds at the core were prepared to investigate the solubility of these architectures, the ability of these molecules to solubilize pyrene as a model drug, and the ability of these architectures to undergo thiol-disulfide exchange. The ability to solubilize pyrene is directly correlated with molecular weight of the dendrimer-aggregation of dendrons does not occur. Thiol-disulfide exchange occurs rapidly using dithiothreitol as the reductant to yield dendrimers with thiol cores that can undergo oxidation in air to yield the original dendrimer.

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Citations

Jul 6, 2013·Expert Opinion on Drug Discovery·Eric E SimanekGiovanni M Pavan
Apr 3, 2012·Advanced Drug Delivery Reviews·Jongdoo Lim, Eric E Simanek
Jan 14, 2012·Journal of the American Chemical Society·Jongdoo LimEric E Simanek
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eric E Simanek

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