Synthesis and Characterization of Chitosan-Coated Near-Infrared (NIR) Layered Double Hydroxide-Indocyanine Green Nanocomposites for Potential Applications in Photodynamic Therapy

International Journal of Molecular Sciences
Pei-Ru WeiChia-Hung Lee

Abstract

We designed a study for photodynamic therapy (PDT) using chitosan coated Mg-Al layered double hydroxide (LDH) nanoparticles as the delivery system. A Food and Drug Administration (FDA) approved near-infrared (NIR) fluorescent dye, indocyanine green (ICG) with photoactive properties was intercalated into amine modified LDH interlayers by ion-exchange. The efficient positively charged polymer (chitosan (CS)) coating was achieved by the cross linkage using surface amine groups modified on the LDH nanoparticle surface with glutaraldehyde as a spacer. The unique hybridization of organic-inorganic nanocomposites rendered more effective and successful photodynamic therapy due to the photosensitizer stabilization in the interlayer of LDH, which prevents the leaching and metabolization of the photosensitizer in the physiological conditions. The results indicated that the polymer coating and the number of polymer coats have a significant impact on the photo-toxicity of the nano-composites. The double layer chitosan coated LDH-NH₂-ICG nanoparticles exhibited enhanced photo therapeutic effect compared with uncoated LDH-NH₂-ICG and single layer chitosan-coated LDH-NH₂-ICG due to the enhanced protection to photosensitizers against photo and ...Continue Reading

References

Jun 24, 1998·Journal of the National Cancer Institute·T J DoughertyQ Peng
Mar 19, 2002·Journal of Photochemistry and Photobiology. B, Biology·Yvette Niamien KonanEric Allémann
Jan 7, 2004·Advanced Drug Delivery Reviews·Cornelus F van Nostrum
Jan 7, 2004·Advanced Drug Delivery Reviews·David Kessel
Jan 7, 2004·Advanced Drug Delivery Reviews·Cornelus F van Nostrum
Nov 3, 2004·Advanced Drug Delivery Reviews·Peter WatsonDavid J Stephens
Jan 5, 2006·Journal of the American Chemical Society·Zhi Ping XuPeter P Gray
Aug 25, 2006·The Journal of Physical Chemistry. B·Zhi Ping XuGao Qing Max Lu
Oct 25, 2007·Clinical Pharmacology and Therapeutics·L ZhangO C Farokhzad
Sep 2, 2008·Nature Reviews. Drug Discovery·Mark E DavisDong M Shin
Sep 25, 2008·Nature Materials·Younan Xia
Jan 26, 2010·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pilar Rivera GilWolfgang J Parak
May 19, 2010·Marine Drugs·Abdelbasset El HadramiFouad Daayf
Apr 5, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·So Jin LeeIck Chan Kwon
Jan 1, 2010·Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques·Manish P PatelJayvadan K Patel
Dec 24, 2011·Journal of the American Chemical Society·Mingfei ShaoXue Duan
Jun 27, 2012·Journal of Biomedical Materials Research. Part a·Govinda KapusettiPralay Maiti
Jul 25, 2012·Nanoscale·Georgiana StoicaEmilio Palomares
Sep 4, 2012·International Journal of Molecular Sciences·Mahboobeh EiliWan Md Zin Wan Yunus
Nov 28, 2012·Advanced Healthcare Materials·Zi GuAnita C Thomas
Jun 26, 2013·European Journal of Dermatology : EJD·Ji-Youn ParkYou Chan Kim
Oct 15, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Kate RossNeil Fenske
Nov 29, 2013·Photodermatology, Photoimmunology & Photomedicine·Fahad AlmutawaHenry W Lim
Nov 29, 2013·Photodiagnosis and Photodynamic Therapy·Ivan Wong Hin Chung, Sam Eljamel
Apr 12, 2014·International Journal of Molecular Sciences·Aminu Umar KuraSamer Hasan Hussein-Al-Ali
May 3, 2014·International Journal of Molecular Sciences·Kai ZhangMing Qian Wei
May 8, 2014·International Journal of Molecular Sciences·Farahnaz BarahuieZulkarnain Zainal
Dec 10, 2014·International Journal of Molecular Sciences·Tae-Hyun KimJae-Min Oh

❮ Previous
Next ❯

Citations

Jan 12, 2017·Small·Yongjiu ChenHuiyu Liu
Mar 25, 2017·International Journal of Cancer. Journal International Du Cancer·Jian-Qin TangGuan Jiang
Oct 5, 2019·Nanomaterials·Wenji Jin, Dae-Hwan Park
Jul 17, 2019·AAPS PharmSciTech·Giovana Maria Fioramonti CalixtoCarla Raquel Fontana
Apr 12, 2020·International Journal of Molecular Sciences·Chia-Hui LinChia-Hung Lee

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
flow cytometry
confocal microscopy
electrophoresis

Software Mentioned

SigmaPlot Systat ( SPSS )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.