Synthesis and Characterization of Novel Fluoro-glycosylated Porphyrins that can be Utilized as Theranostic Agents

ChemistryOpen
Katriann ArjaK Peter R Nilsson

Abstract

Small molecules with modalities for a variety of imaging techniques as well as therapeutic activity are essential, as such molecules render opportunities to simultaneously conduct diagnosis and targeted therapy, so called theranostics. In this regard, glycoporphyrins have proven useful as theranostic agents towards cancer, as well as noncancerous conditions. Herein, the synthesis and characterization of heterobifunctional glycoconjugated porphyrins with two different sugar moieties, a common monosaccharide at three sites, and a 2-fluoro-2-deoxy glucose (FDG) moiety at the fourth site are presented. The fluoro-glycoconjugated porphyrins exhibit properties for multimodal imaging and photodynamic therapy, as well as specificity towards cancer cells. We foresee that our findings might aid in the chemical design of heterobifunctional glycoconjugated porphyrins that could be utilized as theranostic agents.

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Citations

Jul 26, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ncediwe TsolekileOluwatobi Samuel Oluwafemi
Apr 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana R L AraújoJosé A S Cavaleiro
May 14, 2020·International Journal of Molecular Sciences·Hanieh MontaseriHeidi Abrahamse

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Methods Mentioned

BETA
imaging techniques
glycosylation
NMR
Flow cytometry

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