Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine.

Bioinorganic Chemistry and Applications
Jakob KljunIztok Turel

Abstract

Novel ruthenium(III) complexes with histamine [RuCl(4)(dmso-S)(histamineH)] . H( (2) )O (1a) and [RuCl(4)(dmso-S)(histamineH)] (1b) have been prepared and characterized by X-ray structure analysis. Their crystal structures are similar and show a protonated amino group on the side chain of the ligand which is not very common for a simple heterocyclic derivative such as histamine. Biological assays to test the cytotoxicity of the compound 1b combined with electroporation were performed to determine its potential for future medical applications in cancer treatment.

References

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Dec 8, 2004·Current Topics in Medicinal Chemistry·Enzo AlessioGianni Sava
Apr 13, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Paul J Dyson, Gianni Sava
Jul 13, 2007·Nature Reviews. Cancer·Lloyd Kelland
Nov 10, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Trevor W Hambley
Dec 25, 2007·Acta Crystallographica. Section A, Foundations of Crystallography·George M Sheldrick
Jan 10, 2008·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Darren GriffithCeline J Marmion
Jan 1, 1997·Methods in Enzymology·Zbyszek Otwinowski, Wladek Minor

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