Synthesis and Characterization of Novel Polycarbonate Based Polyurethane/Polymer Wrapped Hydroxyapatite Nanocomposites: Mechanical Properties, Osteoconductivity and Biocompatibility

Journal of Biomedical Nanotechnology
M SelvakumarSantanu Chattopadhyay

Abstract

The present investigation reports the preparation of two types of 2D rod-like nano-hydroxyapatite (nHA) (unmodified and Polypropylene glycol (PPG) wrapped) of varying high-aspect ratios, by modified co-precipitation methods, without any templates. These nHA were successfully introduced into novel synthesized Thermoplastic Polyurethane (TPU) matrices based on polycarbonate soft segments, by both in-situ and ex-situ techniques. Physico-mechanical properties of the in-situ prepared TPU/nHA nanocomposites were found to be superior compared to the ex-situ counterparts, and pristine nHA reinforced TPU. Improved biocompatibility of the prepared nanocomposites was confirmed by MTT assays using osteoblast-like MG63 cells. Cell proliferation was evident over an extended period. Osteoconductivity of the nanocomposites was observed by successful formation of an apatite layer on the surface of the samples, after immersion into simulated body fluid (SBF). Prothrombin time (PT) and activated partial thromboplastin time (APTT), as calculated from coagulation assays, displayed an increase in the clotting time, particularly for the PPG-wrapped nHA nanocomposites, prepared through the in-situ technique. Only 0.3% of hemolysis was observed for the...Continue Reading

Citations

Jun 18, 2015·International Journal of Molecular Sciences·Hwa-Jeong LeeIn-Kyu Park
Jul 20, 2016·Journal of Materials Science. Materials in Medicine·Shokoufeh BorhanEbrahim Ghasemi
Sep 24, 2016·International Journal of Oral Science·Chen-Lu LiuZhi-He Zhao
Oct 18, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·M P DrupithaKinsuk Naskar
May 20, 2015·Science and Technology of Advanced Materials·Muthu Vignesh VellayappanMustafa Yusof
Nov 6, 2020·International Journal of Nanomedicine·Selvakani PrabakaranGuolin Meng

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