Mar 8, 2006

Synthesis and characterization of paramagnetic microparticles through emulsion-templated free radical polymerization

Langmuir : the ACS Journal of Surfaces and Colloids
Hao ShangGil U Lee

Abstract

A novel method is described for the preparation of high-magnetization paramagnetic microparticles functionalized with a controlled density of poly(ethylene glycol) (PEG) and carboxyl groups. These microparticles were synthesized using four steps: (1) creation of an oil-in-water emulsion in which hydrophobic iron oxide nanoparticles and a UV-activated initiator were distributed in hexane; (2) formation of uniform microparticles through emulsion homogenization and evaporation of hexane; (3) functionalization of the microparticle with a PEG-functionalized surfactant and acrylic acid; and (4) polymerization of the microparticles. Characterization of the microparticles with electron microscopy and light scattering revealed that they were composed of densely packed iron oxide nanoparticles and that the size of the microparticles may be controlled through the pore size of the membrane used to homogenize the emulsion. The concentration of surfactant and acrylic acid used in the third processing step was found to determine the surface chemistry, iron content, and magnetization of the microparticles. Increasing the PEG surfactant to acrylic acid ratio resulted in higher PEG surface densities, lower iron content, and lower magnetization. ...Continue Reading

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Mentioned in this Paper

Acrylic Acid
n-hexane
Ethylene Glycol Measurement
Surfactant [EPC]
Endogenous Surfactants
Free Radicals
Pulmonary Surfactants
Adsorption
Electron Microscopy, Diagnostic
Acrylate

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