Synthesis and characterization of PLGA-PEG-PLGA based thermosensitive polyurethane micelles for potential drug delivery.

Journal of Biomaterials Science. Polymer Edition
Min WangHong Tan

Abstract

Polyurethane nanomicelle is a promising functional drug delivery system. In this work, the polyurethane (P3-PU) was synthesized from PLGA1200-PEG1450-PLGA1200 (P3, a thermosensitive and biodegradable triblock copolymer) and L-lysine ester diisocyanate (LDI). Then, reactive benzaldehyde was further imported to terminate P3-PU to obtain benzaldehyde modified polyurethane (P3-PUDA). The micelles, temperature-sensitive P3-PU nanomicelle and P3-PUDA nanomicelle, were systematically investigated, including the size, stability, temperature sensitivity, drug loading and release behavior, cytotoxic on human hepatocytes (L02), and inhibitory effect on human hepatocellular carcinoma cells (HepG2). The results show the thermosensitive behavior of the micelles can be adjusted by the terminal group. The polyurethane micelles with a uniform size between 20 nm and 30 nm showed excellent stability and good biocompatibility to L02 cells. Besides, in vitro experiments showed that Dox-loaded P3-PUDA micelles exhibited faster and higher release rate at 37 °C and better inhibitory effect on HepG2 than the Dox-loaded P3-PU micelles. Moreover, the achieved benzaldehyde modified polyurethanes also provides various possibilities to adjust further to enl...Continue Reading

References

Jun 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·G M ZentnerS Weitman
Aug 10, 2002·Science·Dennis E Discher, Adi Eisenberg
Feb 3, 2005·Nature Reviews. Drug Discovery·Vladimir P Torchilin
Jan 30, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jubo LiuChristine Allen
Dec 17, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·H MaedaJ Daruwalla
Aug 4, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Basavaraj K NanjwadeVeerendra K Nanjwade
Nov 4, 2010·Journal of Colloid and Interface Science·Zhimei SongGuangxi Zhai
May 14, 2011·Expert Opinion on Drug Delivery·Zhenqing Li, Jianjun Guan
Nov 8, 2011·Nature Nanotechnology·Jong Ah KimKenneth A Dawson
Nov 8, 2011·Nature Nanotechnology·Huw Summers
Jun 18, 2015·Nanotechnology Reviews·William H Gmeiner, Supratim Ghosh
Jan 10, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Swati BiswasBalaram Ghosh
Nov 12, 2016·Nature Reviews. Cancer·Jinjun ShiOmid C Farokhzad
Oct 19, 2017·International Journal of Nanomedicine·Fakhar Ud DinAlam Zeb
Jun 30, 2018·Chemical Reviews·Horacio CabralKazunori Kataoka
Jan 17, 2020·Journal of Nanobiotechnology·Ming GaoTim Melander Bowden
Apr 7, 2020·Journal of Biomaterials Science. Polymer Edition·Samira KhalediSoodabeh Davaran
Jan 14, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhaoyuan GuoJing Ren
Feb 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Puxiu WangXing Tang
May 16, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xin LiHong Tan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.