Synthesis and characterization of polyion complex micelles and their controlled release of folic acid

Journal of Colloid and Interface Science
Yali LuoQingyu Gao

Abstract

Stable and narrow distribution polyion complex micelles (PICMs) were prepared in an aqueous milieu through electrostatic interaction between a pair of oppositely charged block copolymers poly(N-vinylpyrrolidone)-block-poly(2-acrylamido-2-methyl-1-propanesulfonic acid) (PVP-b-PAMPS) and monomethoxy poly(ethylene glycol)-block-poly(4-vinyl pyridine) (PEG-b-P4VP). The critical aggregate concentration (CAC), hydrodynamic size, and surface morphology of the prepared PICMs were characterized by fluorescence spectroscopy, dynamic light scattering (DLS), and transmission electron microscopy (TEM), respectively. The resulting CAC and the average diameter of the PICMs were about 43 mg/L and 121 nm, indicating high structural stability of micelles and a size favorable for delivery of drug. In addition, the PICMs exhibited good biocompatibility using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay with human embryonic kidney (HEK293) cells. All of these features are quite feasible for utilizing the PICMs as a novel intelligent drug delivery system. In order to assess its application in the biomedical area, the model drug folic acid (FA) was loaded into the micelles and the in vitro drug release behavior was in...Continue Reading

References

May 7, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tomás ReschelKarel Ulbrich
Jun 5, 2004·Journal of Colloid and Interface Science·Isamu KanedaHideo Nakajima
Jun 5, 2004·Journal of Colloid and Interface Science·Tomokazu YoshimuraKunio Esumi
Apr 20, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Sergey V SolomatinAlexander V Kabanov
Sep 27, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Chau-Hui WangGing-Ho Hsiue
Nov 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Geneviève GaucherJean-Christophe Leroux
Jun 17, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Carmen Alvarez-LorenzoAngel Concheiro
Aug 22, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kyung T OhAlexander V Kabanov
Nov 14, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hua WeiRen-Xi Zhuo
Oct 5, 2007·Journal of Colloid and Interface Science·Xiaoyun PanZhengzhong Shao
Dec 25, 2007·Analytica Chimica Acta·Elena V PiletskaSergey A Piletsky
Mar 4, 2008·Colloids and Surfaces. B, Biointerfaces·Kyung Min ParkKi Dong Park
Apr 9, 2008·Journal of Colloid and Interface Science·Dave J AdamsPeter Schuetz
Apr 29, 2008·Journal of Colloid and Interface Science·Xi ChenLinqi Shi
Jan 24, 2009·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Y Y HeXiaoyuan Fan

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