Synthesis and Characterization of Poly(Vinyl Alcohol)-Chitosan-Hydroxyapatite Scaffolds: A Promising Alternative for Bone Tissue Regeneration

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Sergio Pineda-CastilloLukas Munster

Abstract

Scaffolds can be considered as one of the most promising treatments for bone tissue regeneration. Herein, blends of chitosan, poly(vinyl alcohol), and hydroxyapatite in different ratios were used to synthesize scaffolds via freeze-drying. Mechanical tests, FTIR, swelling and solubility degree, DSC, morphology, and cell viability were used as characterization techniques. Statistical significance of the experiments was determined using a two-way analysis of variance (ANOVA) with p < 0.05. Crosslinked and plasticized scaffolds absorbed five times more water than non-crosslinked and plasticized ones, which is an indicator of better hydrophilic features, as well as adequate resistance to water without detriment of the swelling potential. Indeed, the tested mechanical properties were notably higher for samples which were undergone to crosslinking and plasticized process. The presence of chitosan is determinant in pore formation and distribution which is an imperative for cell communication. Uniform pore size with diameters ranging from 142 to 519 µm were obtained, a range that has been described as optimal for bone tissue regeneration. Moreover, cytotoxicity was considered as negligible in the tested conditions, and viability indicat...Continue Reading

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Citations

Nov 30, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andres Bernal-BallenMarian Lehocky
Jan 2, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sylvain Caillol
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Magdalena GłąbAgnieszka Sobczak-Kupiec
Aug 15, 2021·International Journal of Pharmaceutics·Amany A MostafaElham A Hassan
Jul 17, 2019··Ashraq A. KadhmZuhair J. Abd Alameer

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