Synthesis and characterization of thermally and chemically gelling injectable hydrogels for tissue engineering.

Biomacromolecules
Adam K EkenseairAntonios G Mikos

Abstract

Novel, injectable hydrogels were developed that solidify through a physical and chemical dual-gelation mechanism upon preparation and elevation of temperature to 37 °C. A thermogelling, poly(N-isopropylacrylamide)-based macromer with pendant epoxy rings and a hydrolytically degradable polyamidoamine-based diamine cross-linker were synthesized, characterized, and combined to produce in situ forming hydrogel constructs. Network formation through the epoxy-amine reaction was shown to be rapid and facile, and the progressive incorporation of the hydrophilic polyamidoamine cross-linker into the hydrogel was shown to mitigate the often problematic tendency of thermogelling materials to undergo significant postformation gel syneresis. The results suggest that this novel class of injectable hydrogels may be attractive substrates for tissue engineering applications due to the synthetic versatility of the component materials and beneficial hydrogel gelation kinetics and stability.

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Citations

Jul 3, 2013·Tissue Engineering. Part B, Reviews·Henning MadryMagali Cucchiarini
Sep 26, 2014·Journal of the American Chemical Society·Mukesh K GuptaCraig L Duvall
Apr 22, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sytze J BuwaldaWim E Hennink
Nov 28, 2015·International Journal of Molecular Sciences·Michael C Hacker, Hafiz Awais Nawaz
Sep 25, 2012·Advanced Drug Delivery Reviews·Adam K EkenseairAntonios G Mikos
Nov 29, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Leda Klouda
Jan 25, 2014·Journal of Biomedical Materials Research. Part a·Stephanie N TzouanasAntonios G Mikos
Dec 9, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tiffany N VoAntonios G Mikos
Jun 23, 2016·Journal of Biomaterials Science. Polymer Edition·Tiffany N VoAntonios G Mikos
May 7, 2016·Journal of Biomedical Materials Research. Part a·Meryem O Pehlivaner Kara, Adam K Ekenseair
Aug 26, 2016·Journal of Biomedical Materials Research. Part a·Tiffany N VoAntonios G Mikos
Jun 8, 2018·Chemical Communications : Chem Comm·Andreas J D KrügerLaura De Laporte
Jun 20, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Muhammed AnwaryViness Pillay
Nov 23, 2019·Journal of Biomedical Materials Research. Part a·Jason L GuoAntonios G Mikos
Dec 2, 2017·Drug Delivery and Translational Research·Mathieu MaisaniOlivier Chassande
Aug 12, 2018·Journal of Biomaterials Applications·S S PatilRdk Misra
Jul 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Arvind K Singh ChandelSuresh K Jewrajka
Oct 28, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ki Hyun BaeMotoichi Kurisawa
Oct 4, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yu Seon KimAntonios G Mikos
May 1, 2021·Acta Biomaterialia·Jason L GuoAntonios G Mikos
Oct 15, 2020·Chemical Communications : Chem Comm·Chen WangDong Qiu
Dec 9, 2019·ACS Biomaterials Science & Engineering·Yu Seon KimAntonios G Mikos
Aug 30, 2021·Colloids and Surfaces. B, Biointerfaces·Saeid Shabestari KhiabaniSoodabeh Davaran

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