Synthesis and characterization of various 5'-dye-labeled ribonucleosides

Organic & Biomolecular Chemistry
Coralie De SchutterLuigi A Agrofoglio

Abstract

Hitherto unknown chromophoric nucleosides are reported. This novel set of visibly coloured dye-labeled 5'-nucleosides, including 1,2,4,5-tetrazine, dicyanomethylene-4H-pyran, benzophenoxazinone, 9,10-anthraquinone and azobenzene chromophores, were prepared mainly under Cu-catalyzed azide-alkyne cycloaddition (CuAAC). The design criteria are outlined. Several derivatives possess in supplement a fluorescence property. The absorption and fluorescence spectra of all coloured nucleosides were recorded to study their potential as visible-range probes. Such nucleodyes are of great interest for future competitive lateral flow test MIP-based strips.

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Citations

Jul 12, 2020·Chemistry : a European Journal·Lorenzo CasimiroRémi Métivier

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Methods Mentioned

BETA
Fluorescence
column chromatography

Software Mentioned

SpectraManager

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