Synthesis and cytotoxic activity of some novel polycyclic gamma-butyrolactones

Bioorganic & Medicinal Chemistry Letters
M P S IsharSurinderjit Singh Bhella

Abstract

Baeyer-Villiger oxidation of 5-aryl-7,11,11-trimethyltricyclo[5.4.0.0(3,6)]-undec-1-en-4-ones 4a-h by H(2)O(2) and formic acid in methanol yields mixtures of 3b,7,7-trimethyl-3-phenyl-3,3a,3b,4,5,6,7,8a-octahydro-1H-indeno-[1,2-c]furan-1-ones 8a-h and 3b,7,7-trimethyl-3-phenyl-3,3a,3b,4,5,6,7,8a-octahydro-1H-indeno-[1,2-c]furan-2-ones 9a-h in high yields. The obtained butyrolactones 8a-h display cytotoxic activity against a number of human cancer cells.

References

Jul 1, 1990·Journal of Medicinal Chemistry·C D SelassieT A Khwaja
Sep 25, 1998·Phytochemistry·N H FischerS G Franzblau

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Citations

Sep 27, 2014·European Journal of Medicinal Chemistry·Vishal SharmaMohan Paul S Ishar
Jul 31, 2016·European Journal of Medicinal Chemistry·Mahsa Ansari, Saeed Emami

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