Synthesis and degradation of sodium iron phosphate glasses and their in vitro cell response

Journal of Biomedical Materials Research. Part a
A J ParsonsC A Scotchford

Abstract

The degradation profiles of six sodium iron phosphate glass formulations have been investigated using simple dissolution trials in deionized water. The glasses were produced from the appropriate phosphate salts by melting at 1200 degrees C in 5% Au/95% Pt crucibles. Dissolution rates varied from 0.2 gcm(-2)h(-1) for the 1% Fe glass to essentially zero over the 6-week test period for the 15% Fe and 20% Fe glasses. The overall degradation rate was found to vary according to the approximate relation: rate = 1.3e(-0.79x) gcm(-2)h(-1), where x is the percentage iron content of the glass. Glasses with 10% or greater iron content were observed to maintain a constant density over the course of the tests and thus appeared to degrade from the surface and not the bulk. In vitro cell response tests were conducted on the glasses using macrophages and primary craniofacial osteoblasts. These tests were performed on the glasses with 10% or greater iron content because glasses with lower iron content degraded too quickly. Confocal microscopy revealed a rounded macrophage morphology and IL-1beta production was low, suggesting little macrophage activation. However, a significant level of peroxide production was observed. Osteoblasts were observed...Continue Reading

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Citations

Jun 26, 2007·Journal of Materials Science. Materials in Medicine·Delia S BrauerMatthias Schnabelrauch
Jun 15, 2011·Journal of Materials Science. Materials in Medicine·I AhmedC D Rudd
Jul 5, 2012·Journal of Materials Science. Materials in Medicine·M S HasanC A Scotchford
Dec 25, 2012·Journal of the Mechanical Behavior of Biomedical Materials·R M FelfelC D Rudd
Jul 26, 2011·Journal of the Mechanical Behavior of Biomedical Materials·R M FelfelC D Rudd
Sep 2, 2016·Journal of Materials Science. Materials in Medicine·Ross ColquhounK Elizabeth Tanner
Mar 17, 2011·Journal of Physics. Condensed Matter : an Institute of Physics Journal·A J ParsonsM R Johnson
Nov 26, 2010·Journal of Biomedical Materials Research. Part a·C A ScotchfordC D Rudd
Feb 22, 2012·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·A KianiJ C Knowles
Oct 22, 2013·Science and Technology of Advanced Materials·Jianhua ZhangNobutaka Hanagata
Mar 7, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yufang ZhuStefan Kaskel
Oct 12, 2013·Journal of Biomedical Materials Research. Part a·David C BassettJake E Barralet

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