Synthesis and direct comparison of the anticancer activities of phomopsolides D and E and two 7-oxa-/7-aza-analogues

MedChemComm
Alhanouf Z AljahdaliGeorge A O'Doherty

Abstract

The synthesis of two stable phomopsolide natural products (D and E) and two analogues is presented. The cytotoxicities of these four compounds are surveyed and compared across a panel of NCI-cancer cell lines. This analysis found moderate cytotoxicities (2-50 μM) for the majority of the cell lines with phomopsolide D being more active than phomopsolide E and the 7-oxa analogue being commensurately more active than the 7-aza analogue.

References

Dec 11, 1997·Journal of Natural Products·D B StierleB Ganser
Aug 17, 2001·Organic Letters·T J Hunter, G A O'Doherty
May 24, 2003·Organic Letters·Catherine M Smith, George A O'Doherty
Sep 23, 2006·Nature Reviews. Cancer·Robert H Shoemaker
Jun 12, 2013·Journal of the American Chemical Society·Yanping Wang, George A O'Doherty
Jun 6, 2014·ACS Medicinal Chemistry Letters·Hongyi CaiRavit Arav-Boger
Jun 6, 2014·ACS Medicinal Chemistry Letters·Michael F CuccareseGeorge A O'Doherty
Nov 4, 2016·Molecular Cancer Therapeutics·Katarzyna A LudwikDeborah A Lannigan
Mar 16, 2018·ACS Medicinal Chemistry Letters·Xiaofan LiuGeorge A O'Doherty

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