PMID: 6167717Mar 1, 1981Paper

Synthesis and DNA binding of [3-[2'-(2-acetamidoethyl)-2,4'-bithiazole-4-carboxamido]propyl[dimethylsulfonium chloride, a fragment of bleomycin A2

Journal of Medicinal Chemistry
T T SakaiJ D Glickson

Abstract

[3-[2'-(2-Acetamidoethyl)-2,4'-bithiazole-4-carboxamido]propyl]dimethylsulfonium chloride (1), the acetyl derivative of the cationic terminal dipeptide of bleomycin A2, has been synthesized and its binding to DNA and poly(dA-dT) has been studied by proton NMR and fluorescence spectroscopy. The spectral perturbations which occur upon binding of the compound to either nucleic acid indicate that that portion of bleomycin which binds to the nucleic acid can, for the most part, be mimicked by the fragment. The data are discussed in terms of the structure of the drug and the drug-nucleic acid complex.

Citations

Jan 1, 1990·Chemico-biological Interactions·D H PeteringW E Antholine
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J D GlicksonT T Sakai
Dec 1, 1983·Journal of Biomolecular Structure & Dynamics·T T SakaiA Levy
Oct 1, 1986·Journal of Biomolecular Structure & Dynamics·R HoussinJ P Henichart
Oct 20, 2005·Journal of Bioscience and Bioengineering·Masanori Sugiyama, Takanori Kumagai
Nov 21, 2012·Chemical Biology & Drug Design·Xuan Tang, Xiangyang Liang
May 3, 1988·Biochemistry·R P HertzbergS M Hecht
Sep 30, 1983·Toxicology and Applied Pharmacology·R A NewmanT T Sakai
Dec 22, 1988·Nature·R L MillsJ J Farrell
Jan 26, 1996·The Journal of Organic Chemistry·Gang LiDavid J. Jebaratnam

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