Synthesis and DNA cleaving activity of water-soluble non-conjugated thienyl tetraynes

Bioorganic & Medicinal Chemistry
Kohei TorikaiIkuo Ueda

Abstract

Water-soluble non-conjugated thienyl tetraynes (3-6) were synthesized and their DNA cleaving activity was evaluated using electrophoresis, atomic force microscopy (AFM) and Escherichia coli (E. coli) transformation techniques. The amino-functionalized compound 4 was shown to possess an activity to cleave plasmid DNA by both electrophoresis and E. coli transformation techniques. AFM also showed a cleavage of the circular DNA into a linear form with a formation of burst-star-shaped architectures, which were envisaged to be cross-linked DNA oligomers.

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Citations

Sep 30, 2015·The Journal of Organic Chemistry·Sarah L Skraba-JoinerJay Agarwal
May 27, 2017·Journal of the American Chemical Society·Feng XuThomas R Hoye
Apr 2, 2009·Chemical & Pharmaceutical Bulletin·Hidenori KimuraIkuo Ueda
May 7, 2014·Angewandte Chemie·Catherine Holden, Michael F Greaney
Aug 26, 2014·Organic Letters·Brian P WoodsThomas R Hoye
Oct 8, 2011·The Journal of Organic Chemistry·Aida AjazRichard P Johnson

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