Synthesis and effect on human HepG2 cells of 1,2-bis-(2-methylallyl)disulfane.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Chunxiao JiMing Xu

Abstract

1,2-bis(2-methylallyl)disulfane was synthesized from sodium sulfide and 3-chloro-2-methylpropylene. The structure of the target product was confirmed by GC-MS, 1H-NMR and elemental analysis. Cell viability assay, flow-cytometric analysis and protein expression results showed that 1,2-bis(2-methylallyl)disulfane could significantly inhibit the proliferation, and induce the apoptosis of human HepG2 cells.

References

Mar 1, 1993·British Journal of Cancer·E DorantF Sturmans
Apr 1, 1996·Carcinogenesis·S G Sundaram, J A Milner
Jan 15, 2005·Biochemical and Biophysical Research Communications·Tomohiro NabekuraShuji Kitagawa
Sep 28, 2006·Journal of Agricultural and Food Chemistry·Nathalie Druesne-PecolloCatherine Chaumontet
Mar 22, 2007·Journal of Agricultural and Food Chemistry·Hyungeun Yoon, Rui Hai Liu
Mar 27, 2007·Journal of Agricultural and Food Chemistry·Anita SrivastavaGerard Krewer
Jun 5, 2007·Journal of Agricultural and Food Chemistry·Melanie KernDoris Marko
Jul 31, 2007·Journal of Agricultural and Food Chemistry·Elizabeth Jingnan ZhangKathy Qian Luo

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

Quantity One

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