PMID: 11902641Mar 21, 2002Paper

Synthesis and evaluation for biological activity of 3-alkyl and 3-halogenoalkyl-quinoxalin-2-ones variously substituted. Part 4

Il Farmaco
Antonio CartaRoberta Loddo

Abstract

A new series of 3-isopropyl-, 3-trifluoromethyl- and 3-bromomethylquinoxaline-2-ones variously substituted on the benzo-moiety were synthesized and submitted to a preliminary in vitro evaluation for antibacterial, antifungal and anti-HIV activities. Furthermore, all compounds were also tested for cytotoxicity. Results of the screening showed that compound 10 exhibits moderate antimicrobial activity against Staphylococcus aureus (MIC = 33 microM), and that 25 and 26 showed interesting cytotoxicity versus mock-infected MT-4 cells. All the other compounds were inactive.

Citations

Nov 26, 2002·European Journal of Medicinal Chemistry·Antonio CartaRoberta Loddo
Jan 17, 2012·Bioorganic Chemistry·Hisato IshikawaAkihiro Yokoyama
Nov 26, 2014·Chemical Reviews·Bagher Eftekhari-Sis, Maryam Zirak
Nov 22, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Konrad SkotnickiKrzysztof Bobrowski
Apr 3, 2013·Chemical & Pharmaceutical Bulletin·Hisato IshikawaAkihiro Yokoyama
Mar 14, 2018·The Journal of Physical Chemistry. B·Konrad SkotnickiKrzysztof Bobrowski
Apr 10, 2019·The Journal of Physical Chemistry. B·Dafne Díaz-HernándezJulio R De la Fuente

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