Synthesis and evaluation of 4-amino-3,4-dihydro-2H-naphthalen-1-one derivatives as mast cell stabilising and anti-inflammatory compounds

European Journal of Medicinal Chemistry
James W Barlow, John J Walsh

Abstract

A novel series of amine and amide derivatives of 4-amino-3,4-dihydro-2H-naphthalen-1-one were synthesised. The amine derivatives were evaluated for mast cell stabilising activity in rodent mast cell preparations against the reference compound disodium cromoglycate and found to possess significant activity in vitro. The amide compounds were evaluated in an in vivo murine model for anti-inflammatory activity.

References

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Apr 10, 2003·Journal of the American Chemical Society·Fehmi Damkaci, Philip DeShong
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Apr 28, 2006·The FEBS Journal·Jenny Hallgren, Gunnar Pejler

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Citations

Feb 28, 2013·British Journal of Pharmacology·D F Finn, J J Walsh
Jul 2, 2015·European Journal of Pharmacology·Tao ZhangJohn Jarlath Walsh
Aug 13, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Yue SunYun Hou

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