Synthesis and evaluation of a novel water-soluble high Se-enriched Astragalus polysaccharide nanoparticles

International Journal of Biological Macromolecules
Yongbin MengYuangang Zu

Abstract

Selenium is an essential trace element in human body. Se-deficiency is common phenomenon in all over the world, which severely harms the health of organism and causes the etiology of many chronic, degenerative diseases, such as atherosclerosis, arthritis, cancers, hypoimmunity, hypothyroidism and viral diseases. So, the research on preparation of Se-supplementing with the effective, safe and high Se content was imperative. In this study, Se-enriched Astragalus polysaccharide nanoparticles (Se-APS) were prepared by the previous optimization experimental conditions, as follows: reaction temperature 80.5 °C, pH 7.8, ratio of catalyst to APS 0.57:1.0 g·g-1, and reaction time 62 min. The Se content of Se-APS was as high as 13.42 ± 0.37%, characterized by energy spectrometer, thermogravimetry, X-ray diffraction, fourier transform infrared, particle size, zeta potential and atomic force. Se release of the Se-APS in vitro followed the Higuchi's kinetics model and exhibited the basically same release pattern in artificial gastric juice (pH 2.0), artificial intestinal juice (pH 8.0) and PBS (pH 7.4). The proliferation of T-lymphocytes with Se-APS incubation increased at an average of 13.87%, comparing with APS. It could not only enhance ...Continue Reading

Citations

Nov 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cristina MellinasMaría Del Carmen Garrigós
Jun 23, 2020·Critical Reviews in Food Science and Nutrition·Xiao-Dan ShiShao-Yun Wang
Oct 30, 2020·International Journal of Biological Macromolecules·Yu ZhengXiaofang Li

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