Synthesis and evaluation of cytotoxic activity of arylfurans

European Journal of Medicinal Chemistry
Renata B de OliveiraCarlos Leomar Zani

Abstract

A series of 2-aryl and 2,5-diarylfurans were synthesized and evaluated for their in vitro cytotoxicity against human cancer cells lines and on the proliferation of human peripheral blood mononuclear cells (PBMC) stimulated with phytohemaglutinin (PHA). Three compounds were found to present significant activity against the cancer cell lines without affecting the lymphocyte proliferation in PBMCs, indicating low toxicity to normal cells.

References

Jul 13, 2006·Memórias do Instituto Oswaldo Cruz·Renata B de OliveiraCarlos L Zani

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Citations

Jun 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eduarda C CostaCarla C P Arruda
Jan 30, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gisell Apicela SoaresElaine Maria de Souza-Fagundes
Jul 15, 2021·The Journal of Physical Chemistry. a·Daniel M AdrionSteven A Lopez
Nov 23, 2021·Chemistry, an Asian Journal·Leonid V RomashovValentine P Ananikov
Jan 29, 2022·Molecular Diversity·Gabriel Corrêa VeríssimoVinícius Gonçalves Maltarollo

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