Synthesis and evaluation of hydroponically alginate nanoparticles as novel carrier for intravenous delivery of propofol

Journal of Materials Science. Materials in Medicine
Alireza Hassani NajafabadiSina Farzaneh

Abstract

Commercial lipid emulsion of propofol (CLE) has several drawbacks including pain on injection and emulsion instability. In this paper, a novel nanocarrier system is introduced to improve stability and solubility of the poorly soluble anesthetic drug, propofol, for intravenous administration. In this paper, alginate is modified using a facile method in which the carboxylic group of alginate is grafted to octanol. The octanol-grafted alginate (Alg-C8) is then employed to prepare nanoparticles which are subsequently used for encapsulation of propofol. The nanoparticles are analyzed for their pH, osmolarity, particle size, stability, morphology and sleep recovery and the results are compared with CLE as control. It is revealed that nanoparticles have the average particle size of 180 nm ± 1.2 and spherical morphology which is less than CLE while their pH, osmolarity and profile of release of formulated nanoparticles are similar to those of CLE. In addition, the results show good chemical and physical storage stability for the nanoparticles at room temperature for at least 6 months compared to CLE as control. The animal sleep recovery test on rats shows no significant difference in time of unconsciousness and recovery of the righting...Continue Reading

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Citations

Jun 29, 2017·International Journal of Biological Macromolecules·Mengyi CongXia Zhao
Sep 25, 2017·Journal of Biomedical Materials Research. Part a·Tolou HosseinifarMehdi Shafiee Ardestani
May 22, 2020·The Journal of Pharmacy and Pharmacology·Ayat AbdelkaderMahmoud Elsabahy
Feb 5, 2021·Journal of Biomaterials Science. Polymer Edition·Wenjia ZhangMeng Suo

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