PMID: 1800636Sep 1, 1991Paper

Synthesis and evaluation of hydroxylated flavones and related compounds as potential inhibitors of the protein-tyrosine kinase p56lck

Journal of Natural Products
M CushmanR L Geahlen

Abstract

An array of hydroxylated flavones and related compounds was synthesized and evaluated for inhibition of the in vitro protein-tyrosine kinase activity of p56lck, an enzyme that is thought to play a key role in mediating signal transduction from the CD4 receptor during lymphocyte activation. In general, the most active compounds had hydroxyl groups on both the A and C rings. At least two hydroxyl groups were required for good inhibitory activity, and the relative positions of these groups played an important role in determining potency. Compounds without hydroxyl groups were inactive as inhibitors.

Citations

Dec 15, 1995·Journal of Ethnopharmacology·A NickO Sticher
Oct 17, 2013·The International Journal of Biochemistry & Cell Biology·Divyashree RavishankarHelen M I Osborn
Feb 26, 2004·Bioorganic & Medicinal Chemistry·Abhilash ThakurMamta Thakur
Oct 14, 2003·Bioorganic & Medicinal Chemistry Letters·Nicholas J LawrenceJohn A Hadfield
Mar 2, 2016·Bioorganic & Medicinal Chemistry·Pallavi RajaputraYoungjae You
Jul 11, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tzenge-Lien ShihYau-Hung Chen
Sep 30, 2010·Natural Product Reports·Alok Kumar Verma, Ram Pratap
Jul 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ni ZhangWei-Dong Pan
Jul 1, 2016·Comprehensive Reviews in Food Science and Food Safety·Jakub Treml, Karel Šmejkal
Aug 24, 2000·Journal of Chemical Information and Computer Sciences·M OblakT Solmajer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.