Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1

Bioorganic & Medicinal Chemistry Letters
Baogen WuYun He

Abstract

The synthesis and preliminary structure-activity relationship of a series of pyrrolidinones are described. These pyrrolidinones have been characterized as novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) which are highly potent against wild-type and drug-resistant human immunodeficiency viruses (HIV-1).

Citations

Mar 5, 2016·Chemical Reviews·Manoj B GawandeRajender S Varma
Apr 5, 2011·Expert Opinion on Therapeutic Patents·Peng Zhan, Xinyong Liu
Jan 1, 2010·Chemical Science·David S Surry, Stephen L Buchwald
Dec 12, 2012·Organic & Biomolecular Chemistry·Antonio FranconettiFrancisca Cabrera-Escribano
Dec 5, 2009·Journal of the American Chemical Society·Ying-Chieh WongChien-Hong Cheng

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