Synthesis and evaluation of single-wall carbon nanotube-paclitaxel-folic acid conjugate as an anti-cancer targeting agent

Artificial Cells, Nanomedicine, and Biotechnology
Sara TavakolifardMohammad H Moslemin

Abstract

Single-wall carbon nanotubes (SWCNT) represent a novel nanomaterial applied in various nanotechnology fields because of their surface chemistry properties and high drug cargo capacity. In this study, SWCNT are pre-functionalized covalently with paclitaxel (PTX) - an anticancer drug, and folic acid (FA), as a targeting agent for many tumors. The samples are investigated and evaluated by different analyses such as Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), absorption spectroscopic measurements (UV-Visible), elemental analysis, and cell analyses with cancer cell line cultures. The results show good conjugation of the targeting molecule and the anticancer drug on the surface of the carbon nanotubes (CNT). This work demonstrates that the SWCNT-PTX-FA system is a potentially useful system for the targeted delivery of anticancer drugs.

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Citations

Feb 19, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Sumandeep KaurNarendra Kumar Jain
Oct 4, 2019·Current Drug Metabolism·Siyu GuanJihui Tang
Jun 6, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Marc Fakhoury
Dec 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yukang MaoHuicai Huang

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