Synthesis and evaluation of some new substituted benzothiazepine and benzoxazepine derivatives as anticonvulsant agents

European Journal of Medicinal Chemistry
Neha GargAshok Kumar

Abstract

A new series of 4-(4'-Hydroxyphenyl)-2-(3-substitutedphenyl)-3-(4-substitutedphenylamino methylene)-2,3-dihydro-1,5-benzothiazepines (3a-3j) and 4-(4'-Hydroxyphenyl)-2-(3-substituted phenyl)-3-(4-substitutedphenylaminomethylene)-2,3-dihydro-1,5-benzoxazepins (3a'-3j') were synthesized and evaluated for their anticonvulsant activity. All these compounds were screened in vivo, for their anticonvulsant activity and acute toxicity. Compound 3g was found to be most potent compound of this series and was compared with the reference drug phenytion sodium. The structures of these compounds have been established by IR, (1)H NMR and (13)C NMR spectroscopic data.

Citations

Dec 3, 2014·European Journal of Medicinal Chemistry·Gheorghe Roman
Oct 11, 2016·European Journal of Medicinal Chemistry·Tianxian LiBaoan Song
Feb 10, 2017·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Patel NavinGildardo Rivera
Apr 13, 2012·Organic & Biomolecular Chemistry·Olivier MahéJean-François Brière

Related Concepts

Anticonvulsants
Medicinal Plants Testing, Preclinical
In Vivo NMR Spectroscopy
Infrared Spectrophotometry
Mass Spectrometry
Thiazepines
Benzoxazinoids
Anticonvulsants
2-3A-C
Hepatocyte Nuclear Factor 3-gamma

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