Synthesis and Evaluation of the Anti-Oxidant Capacity of Curcumin Glucuronides, the Major Curcumin Metabolites

Antioxidants
Ambar K ChoudhuryMuhammed Majeed

Abstract

Curcumin metabolites namely curcumin monoglucuronide and curcumin diglucuronide were synthesized using an alternative synthetic approach. The anti-oxidant potential of these curcumin glucuronides was compared with that of curcumin using DPPH scavenging method and Oxygen Radical Absorbance Capacity (ORAC) assay. The results show that curcumin monoglucuronide exhibits 10 fold less anti-oxidant activity (DPPH method) and the anti-oxidant capacity of curcumin diglucuronide is highly attenuated compared to the anti-oxidant activity of curcumin.

References

Aug 17, 2002·Organic Letters·You-Min SunCheng-Bu Liu
Apr 3, 2003·Nature Reviews. Cancer·S Perwez HussainCurtis C Harris
Jan 14, 2005·Molecular and Cellular Biochemistry·Marian ValkoJoshua Telser
Mar 17, 2005·Journal of Agricultural and Food Chemistry·Dejian HuangRonald L Prior
Jan 18, 2007·Journal of Agricultural and Food Chemistry·Erika PfeifferManfred Metzler
Mar 21, 2007·Accounts of Chemical Research·Grzegorz Litwinienko, K U Ingold
Jul 14, 2007·Molecular Nutrition & Food Research·Simone I HoehleManfred Metzler
Nov 15, 2007·Molecular Pharmaceutics·Preetha AnandBharat B Aggarwal
Jan 20, 2009·Journal of Agricultural and Food Chemistry·Timothy H MarczyloAndreas J Gescher
Sep 10, 2009·Journal of Agricultural and Food Chemistry·Jian-Ying Feng, Zai-Qun Liu
Jan 1, 2008·Annals of Indian Academy of Neurology·Shrikant Mishra, Kalpana Palanivelu
Apr 8, 2010·Mini Reviews in Medicinal Chemistry·Subhash PadhyeFazlul H Sarkar
Oct 14, 2010·Chemical Reviews·Zai-Qun Liu
Mar 19, 2011·Journal of Natural Products·John CuomoBrian M Dixon
Jan 25, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aslan M EsmurzievBård Helge Hoff
Mar 6, 2012·Trends in Molecular Medicine·Liang Shen, Hong-Fang Ji
Jun 2, 2012·Trends in Molecular Medicine·Odaine N Gordon, Claus Schneider
Jul 10, 2012·Diabetes Care·Somlak ChuengsamarnSiwanon Jirawatnotai
Sep 28, 2013·BMC Complementary and Alternative Medicine·Jhankar D Acharya, Saroj S Ghaskadbi
Nov 28, 2013·Bioorganic & Medicinal Chemistry·Ashutosh PalWilliam G Bornmann
May 24, 2014·Phytotherapy Research : PTR·Yunes PanahiAmirhossein Sahebkar
May 31, 2014·BioMed Research International·Soheil Zorofchian MoghadamtousiKeivan Zandi
Jan 1, 2014·Comprehensive Reviews in Food Science and Food Safety·Seyed Fazel NabaviSeyed Mohammad Nabavi

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Citations

May 23, 2018·Critical Reviews in Food Science and Nutrition·Arpita Banerjee, Pubali Dhar
Feb 2, 2019·Journal of Biomedical Materials Research. Part a·Monika PatelKazuaki Matsumura
Sep 16, 2018·Cell Biochemistry and Biophysics·Arina L DudylinaEnno K Ruuge
Jun 7, 2019·Drug Development and Industrial Pharmacy·Yongshun SunZhiying Zhao
Jul 18, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Aman KhannaRatheesh Mohanan
Aug 3, 2019·Biogerontology·Wioleta GrabowskaAnna Bielak-Zmijewska
Jun 7, 2020·Cell Biochemistry and Biophysics·Fisayo OlotuMahmoud E S Soliman
Aug 3, 2021·Stem Cells International·Khadijeh KhezriFarzaneh Lotfipour
Feb 23, 2019·Journal of Natural Products·Andrew G KunihiroJanet L Funk
Aug 28, 2021·Nutrients·Hitoshi OzawaTeruo Miyazawa
Sep 13, 2021·Molecular Nutrition & Food Research·Tariful IslamNaima Moustaid-Moussa

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Methods Mentioned

BETA
column chromatography
Assay
Fluorescence
SPLET

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