Synthesis and examination of sulfated cyclofructans as a novel class of chiral selectors for CE

Electrophoresis
Chunxia JiangDaniel W Armstrong

Abstract

Cyclofructans (CFs) are a class of cyclic oligosaccharides with a crown ether skeleton. No enantioseparations have previously been reported using this class of chiral oligosaccharides in chromatography or electrophoresis. CFs and their sulfated derivatives were examined as chiral selectors using CE. The native CFs showed no enantioselectivity toward any tested compounds, while the sulfated CFs showed exceptional selectivity toward many cationic analytes, including primary, secondary, and tertiary amines and amino acids. Enantiomeric resolution factors as high as 15.4 were achieved within short analysis times (generally below 10 min). The effect of buffer type, buffer concentration, buffer pH, chiral selector concentration and organic modifier concentration was examined and optimized.

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Citations

Sep 9, 2015·Electrophoresis·Yun-Cheol NaDaniel W Armstrong
Apr 1, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Fumihiko Kitagawa, Koji Otsuka
Dec 21, 2010·Journal of Chromatography. a·Haixiao QiuDaniel W Armstrong
Jan 4, 2012·Electrophoresis·Véréna PoinsotFrançois Couderc
Jun 29, 2011·Journal of Separation Science·Nilusha L T Padivitage, Daniel W Armstrong
Sep 8, 2011·Journal of Separation Science·Lucie JanečkováEva Tesařová
Nov 20, 2012·Electrophoresis·Despina A TsioupiConstantina P Kapnissi-Christodoulou
Sep 30, 2014·Electrophoresis·Ioannis J StavrouConstantina P Kapnissi-Christodoulou
Feb 11, 2015·Journal of Liquid Chromatography & Related Technologies·Nilusha L PadivitageAlain Berthod
Jun 20, 2016·Journal of Chromatography. a·Gerhard K E Scriba
Aug 30, 2016·Journal of Separation Science·Sheng-Ming Xie, Li-Ming Yuan
Dec 7, 2016·Electrophoresis·Ioannis J StavrouConstantina P Kapnissi-Christodoulou
Nov 20, 2018·Electrophoresis·Athina G NicolaouConstantina P Kapnissi-Christodoulou
Jun 3, 2020·Critical Reviews in Analytical Chemistry·Anna W Sobańska
May 26, 2010·Analytical Chemistry·Nicholas W FrostMichael T Bowser

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