Synthesis and immunologic properties in mice of vaccines composed of Staphylococcus aureus type 5 and type 8 capsular polysaccharides conjugated to Pseudomonas aeruginosa exotoxin A.

Infection and Immunity
A FattomJ B Robbins

Abstract

Epidemiological, serological and in vitro phagocytosis experiments provide evidence that the newly discovered type 5 and type 8 capsular polysaccharides (CPs) are both virulence factors and protective antigens for bacteremia caused by Staphylococcus aureus. Neither type 5 nor type 8 CP elicited serum antibodies when injected into mice. These two CPs were bound to Pseudomonas aeruginosa exotoxin A (ETA) to form conjugates by using the synthetic scheme devised for the CP (Vi) of Salmonella typhi and of pneumococcus type 12F (A. Fattom, W. F. Vann, S. C. Szu, A. Sutton, X. Li, D. Bryla, G. Schiffman, J. B. Robbins, and R. Schneerson, Infect. Immun. 56:2292-2298, 1988; S. C. Szu, A. L. Stone, J. D. Robbins, R. Schneerson, and J. B. Robbins, J. Exp. Med. 166:1510-1524, 1987). Both S. aureus CP-ETA conjugates elicited a rise in CP antibodies. As components of conjugates, both S. aureus CPs acquired T-cell-dependent properties, as shown by their ability to respond to carrier priming and to stimulate booster responses. The conjugate-induced antibodies facilitated type-specific opsonization of S. aureus by human polymorphonuclear leukocytes. The conjugates also induced ETA antibodies which neutralized the native toxin in vitro. Clinical...Continue Reading

References

Sep 19, 1978·Biochemistry·R J Ivatt, C Gilvarg
Jan 1, 1978·Annals of Internal Medicine·J F DobkinN H Steigbigel
Mar 1, 1978·The Journal of Clinical Investigation·P K PetersonJ Verhoef
Jul 1, 1977·Journal of Bacteriology·D F Liau, J H Hash
May 4, 1989·The New England Journal of Medicine·W Brumfitt, J Hamilton-Miller
Apr 1, 1986·Infection and Immunity·S J CryzR Germanier
Sep 1, 1987·Annales De L'Institut Pasteur. Microbiology·J M FournierW F Vann
Oct 1, 1987·Journal of Clinical Microbiology·J M FournierH K Hochkeppel
Dec 1, 1987·The Journal of Infectious Diseases·R D Arbeit, R M Dunn
Feb 1, 1987·The Journal of Infectious Diseases·R D Arbeit, M J Nelles
Oct 10, 1985·Journal of Immunological Methods·A SuttonR Schneerson
Sep 1, 1985·Journal of Clinical Microbiology·W W KarakawaJ B Robbins
Apr 1, 1984·Diagnostic Microbiology and Infectious Disease·R D ArbeitJ B Robbins
May 24, 1984·The New England Journal of Medicine·J N Sheagren
Jul 1, 1984·Infection and Immunity·J M FournierW W Karakawa
Jun 16, 1983·Carbohydrate Research·S V MurthyJ H Hash
Sep 1, 1981·Infection and Immunity·B F King, B J Wilkinson

❮ Previous
Next ❯

Citations

Sep 4, 2014·Infection and Immunity·Sabine RauchDominique Missiakas
Jan 11, 2020·Organic & Biomolecular Chemistry·Satsawat VisansirikulAlexei V Demchenko
May 17, 2005·Anais Da Academia Brasileira De Ciências·Christopher Jones
Jan 17, 2004·Clinical Microbiology Reviews·Katherine O'Riordan, Jean C Lee
Oct 3, 2006·FEMS Immunology and Medical Microbiology·Terri K WadeWilliam F Wade
Jul 30, 2015·Australian Veterinary Journal·J Gogoi-TiwariT K Mukkur
Feb 1, 1996·Annals of Medicine·A I Fattom, R Naso
Nov 28, 2001·Current Infectious Disease Reports·Jean C. Lee
Oct 7, 2004·Journal of Bacteriology·Joanna Kubler-KielbRachel Schneerson
Feb 15, 2002·The New England Journal of Medicine·Henry ShinefieldRobert Naso
Apr 23, 2014·The Journal of Biological Chemistry·Yvonne Gar-Yun ChanDominique Missiakas
Aug 1, 1993·Journal of Dairy Science·R J Yancey
Apr 30, 2003·Journal of Molecular Recognition : JMR·Elizabeth Hong-Geller, Goutam Gupta
Nov 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yukiko K Stranger-JonesOlaf Schneewind
Apr 23, 2016·Scientific Reports·Martina SelleKnut Ohlsen
Aug 17, 2016·The Journal of Experimental Medicine·Dominique Missiakas, Olaf Schneewind
Feb 11, 2012·Clinical and Vaccine Immunology : CVI·Paulraj K LawrenceWendy C Brown
Feb 6, 2021·Frontiers in Immunology·Grace R PidwillSimon J Foster
Nov 29, 2017·Human Vaccines & Immunotherapeutics·Ingrid L ScullyAnnaliesa S Anderson
May 28, 2019·Frontiers in Microbiology·Tarcisio BrignoliIsabel Delany
Aug 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Archanamayee Behera, Suvarn S Kulkarni
Mar 23, 2017·The Journal of Infectious Diseases·Hatice KarauzumSandip K Datta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.