Synthesis and immunological evaluation of N-acyl modified Tn analogues as anticancer vaccine candidates

Bioorganic & Medicinal Chemistry
Chengcheng SongXin-Shan Ye

Abstract

Tumor-associated carbohydrate antigens (TACAs), which are aberrantly expressed on the surface of tumor cells, are important targets for anticancer vaccine development. Herein, several N-acyl modified Tn analogues were synthesized and conjugated with carrier protein CRM197. The immunological results of these glycoconjugates indicated that 6-CRM197 elicited higher titers of antibodies which cross-reacted with native Tn antigen than the unmodified 2-CRM197 did. The IFN-γ-producing frequency of lymphocytes in mice treated with 6-CRM197 was obviously increased, compared to that of mice vaccinated with 2-CRM197 (p=0.016), which was typically associated with the Th1 response. Moreover, the elicited antisera against antigen 6-CRM197 reacted strongly with the Tn-positive tumor cells, implying the potential of this glycoconjugate as an anticancer vaccine.

Citations

Mar 8, 2018·Medicinal Research Reviews·Meng-Man WeiXin-Shan Ye
Jun 14, 2016·Organic & Biomolecular Chemistry·Yang YuXin-Shan Ye
Jul 4, 2019·Glycoconjugate Journal·Chengcheng SongYifa Zhou
Sep 10, 2020·Chemistry : a European Journal·Rachel Hevey

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