Synthesis and in vitro antimicrobial activity of some novel substituted benzimidazole derivatives having potent activity against MRSA

European Journal of Medicinal Chemistry
M TunçbilekNurten Altanlar

Abstract

The novel benzimidazole derivatives (3, 5, 8, 9, 12-14, 18-41) were prepared in this paper and the antimicrobial activities of these compounds against Staphylococcus aureus, methicillin-resistant S. aureus (MRSA, standard and clinical isolates), Bacillus subtilis, Escherichia coli and Candida albicans were evaluated. Compounds 24-26 which have no substitution of N-1 position displayed better antibacterial activities than those of standards (ciprofloxacin, ampicillin and sultamicillin) against both the drug-resistant bacteria (MRSA, standard and clinical isolates). These derivatives (24-26), 2,5,6-trihalogenobenzimidazole analogues (8, 12), 5,6-dichloro-2-amino derivative (13), and 5-chloro-2-(4-benzyloxyphenyl)benzimidazole (35) exhibited the most potent antibacterial activity with MIC 3.12 microg/ml against S. aureus.

Citations

Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Nurasyikin HamzahHoong-Kun Fun
Oct 1, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chunli LiuJian Li
Jan 9, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Yetkin GökSevil Albayrak
Jan 19, 2013·Journal of Enzyme Inhibition and Medicinal Chemistry·Emre MenteşeBahittin Kahveci
Jul 3, 2015·Oxidative Medicine and Cellular Longevity·Szabolcs GergelyLászló Virág
Aug 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nafiz Öncü CanÖzgür Devrim Can
Feb 15, 2018·International Journal of Medicinal Chemistry·Afzal Basha ShaikShahanaaz Shaik
Oct 20, 2018·Expert Opinion on Therapeutic Targets·Bing Han, Louis M Weiss
Sep 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cheng-Ying HsiehMing-Hua Hsu
Sep 5, 2018·Current Drug Discovery Technologies·Anuj KumarSushil Kumar
Apr 7, 2011·Archiv der Pharmazie·Yusuf OzkayIlhan Işıkdağ
Nov 2, 2017·Mini Reviews in Medicinal Chemistry·Yogita BansalGulshan Bansal
Aug 7, 2019·BMC Chemistry·Sumit TahlanBalasubramanian Narasimhan
Jan 10, 2012·Bioorganic & Medicinal Chemistry Letters·Hamad M AlkahtaniShudong Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.