Synthesis and in vitro antitumor activity of ring C and D-substituted phenanthrolin-7-one derivatives, analogues of the marine pyridoacridine alkaloids ascididemin and meridine

Bioorganic & Medicinal Chemistry
Evelyne DelfourneFrancis Darro

Abstract

A series of cycle C and D-substituted phenanthrolin-7-ones, analogues of the marine pyridoacridines meridine and ascididemin have been synthesized on the basis of Diels-Alder reactions involving quinoline-5,8-dione and 2- (or un)-substituted-N,N-dimethylhydrazones. All the compounds were evaluated for in vitro cytotoxic activity against 12 distinct human cancer cell lines. They all exhibit cytotoxic activity with IC(50) values at least of micromolar order.

Citations

Dec 15, 2015·Beilstein Journal of Organic Chemistry·Louis P SandjoMaique W Biavatti
Mar 14, 2019·Mini Reviews in Medicinal Chemistry·Jia-Chun LiuWen Zhang
Dec 12, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Jesús ValladolidBegoña García
Jul 12, 2017·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Petar ČanovićŽivadin D Bugarčić
Oct 4, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Muhib AhmedBrendan Twamley
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gabriela ChabowskaAnna Wójcicka
Sep 23, 2014·The Journal of Organic Chemistry·Hao YinZhu-Jun Yao

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