Synthesis and in vitro biological properties of novel cationic derivatives of amphotericin B

Chemistry : a European Journal
Valérie PaquetErick M Carreira

Abstract

Novel cationic amphotericin B derivatives as highly potent antifungal agents are reported. These semi-synthetic derivatives of amphotericin B were elaborated through a series of modifications both on the nitrogen atom of the mycosamine and on the C-16 carboxylic acid moiety. The antifungal activity of the new conjugates was tested against Saccharomyces cerevisiae and also against nine different strains of Candida albicans and Candida glabrata, including an amphotericin resistant strain. High potency was observed in the case of polyamine derivatives bearing two 3-aminopropyl chains on the mycosamine. The evaluation of the biological properties also included the determination of the hemolytic activity of the compounds by measuring the EH50 values.

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Citations

Aug 27, 2009·Applied Microbiology and Biotechnology·Domingo MiranzoFrancisco Malpartida
May 30, 2013·Antimicrobial Agents and Chemotherapy·Anna N TevyashovaMaria N Preobrazhenskaya
Jun 14, 2014·Medical Microbiology and Immunology·Joanna Boros-MajewskaDavid W Williams
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Jun 23, 2009·Chemistry : a European Journal·Alex M SzpilmanErick M Carreira
Nov 16, 2010·Angewandte Chemie·Alex M Szpilman, Erick M Carreira
Jun 27, 2012·Organic & Biomolecular Chemistry·Joaquim NebotFèlix Urpí
Feb 2, 2021·Infectious Diseases and Therapy·Francelise B CavassinFlávio Queiroz-Telles
Mar 27, 2010·Organic Letters·Ock-Youm Jeon, Erick M Carreira
Feb 12, 2019·The Journal of Organic Chemistry·Palika AbayakoonSpencer J Williams

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