Synthesis and in vitro characterizations of porous carboxymethyl cellulose-poly(ethylene oxide) hydrogel film

Biomaterials Research
Su Yeon LeeInsup Noh

Abstract

Cellulose and its derivatives such as carboxymethyl cellulose (CMC) have been employed as a biomaterial for their diverse applications such as tissue engineering, drug delivery and other medical materials. Porosity of the scaffolds has advantages in their applications to tissue engineering such as more cell adhesion and migration leading to better tissue regeneration. After synthesis of CMC-poly(ethylene oxide) (PEO) hydrogel by mixing the solutions of both CMC-acrylate and PEO-hexa-thiols, fabrication and evaluation of a CMC-PEO gel and its film in porous form have been made for its possible applications to tissue regeneration. Physicochemical and biological properties of both CMC-PEO hydrogel and porous films have been evaluated by using physicochemical assays by SEM, FTIR and swelling behaviors as well as in vitro assays of MTT, Neutral red, BrdU, gel covering and tissue ingrowth into the pores of the CMC-PEO gel films. Degradation of CMC-PEO hydrogel was also evaluated by treating with esterase over time. Chemical grafting of acrylate to CMC was verified by analyses of both FTIR and NMR. CMC-PEO hydrogel was obtained by mixing two precursor polymer solutions of CMC-acrylate and PEO-hexa-thiols and by transforming into a por...Continue Reading

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Citations

Jun 28, 2016·Journal of Biomedical Materials Research. Part a·Xingyou HuLu Wang
Jun 1, 2017·Biotechnology Advances·Sheva NaahidiP Chen
Jan 27, 2018·Journal of Functional Biomaterials·Jensen DoucetDaniel Boyd
Apr 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cornelia VasileMihaela Baican
Dec 19, 2019·Frontiers in Bioengineering and Biotechnology·Jing SunYangzi Jiang
Jul 7, 2018·Nanomaterials·Mihaela BalasAnca Dinischiotu
Jan 24, 2021·Carbohydrate Polymers·Allen ZenniferDhakshinamoorthy Sundaramurthi

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Methods Mentioned

BETA
infrared spectroscopy
scanning electron microscopy
light microscopy
fluorescence microscopy

Software Mentioned

SPSS
UTHSCSA Image Tool

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