Abstract
Cellulose and its derivatives such as carboxymethyl cellulose (CMC) have been employed as a biomaterial for their diverse applications such as tissue engineering, drug delivery and other medical materials. Porosity of the scaffolds has advantages in their applications to tissue engineering such as more cell adhesion and migration leading to better tissue regeneration. After synthesis of CMC-poly(ethylene oxide) (PEO) hydrogel by mixing the solutions of both CMC-acrylate and PEO-hexa-thiols, fabrication and evaluation of a CMC-PEO gel and its film in porous form have been made for its possible applications to tissue regeneration. Physicochemical and biological properties of both CMC-PEO hydrogel and porous films have been evaluated by using physicochemical assays by SEM, FTIR and swelling behaviors as well as in vitro assays of MTT, Neutral red, BrdU, gel covering and tissue ingrowth into the pores of the CMC-PEO gel films. Degradation of CMC-PEO hydrogel was also evaluated by treating with esterase over time. Chemical grafting of acrylate to CMC was verified by analyses of both FTIR and NMR. CMC-PEO hydrogel was obtained by mixing two precursor polymer solutions of CMC-acrylate and PEO-hexa-thiols and by transforming into a por...Continue Reading
References
Jan 1, 1990·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G SevillanoD Rodríguez-Puyol
Jan 1, 1989·Journal of Biomedical Materials Research·T MiyamotoY Noishiki
Sep 1, 1994·Cell Transplantation·M B YangD E Ingber
Apr 1, 1993·Biomaterials·A G MikosR Langer
Sep 15, 1998·The Journal of Surgical Research·Y KinoM Mito
Dec 5, 1998·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·M MärtsonP Saukko
Apr 7, 1999·The Biochemical Journal·J G DohenyD G Kilburn
Oct 27, 1999·Biomaterials·M MärtsonP Saukko
Feb 24, 2001·Journal of Biomedical Materials Research·M V Risbud, R R Bhonde
Aug 8, 2001·Clinical Oral Implants Research·T TakataM Miyauchi
May 30, 2002·Biomaterials·Loredana De BartoloEnrico Drioli
Oct 16, 2002·The International Journal of Biochemistry & Cell Biology·Breda CullenNicholas D Light
May 19, 2004·Biomaterials·Emilia EntchevaYordan Kostov
Aug 7, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Eve Ruel-Gariépy, Jean-Christophe Leroux
Feb 4, 2006·Biotechnology Progress·Ram Mohan Kripa RamananKytai T Nguyen
Aug 1, 2006·Drug Delivery·Rassoul DinarvandMohammad Erfan
May 29, 2007·Journal of Biomedical Materials Research. Part a·Mi-Sook KimGiyoong Tae
Dec 29, 2009·Acta Biomaterialia·Qi XingYuri M Lvov
Sep 9, 2010·Biofabrication·Chang Mo HwangAli Khademhosseini
Oct 27, 2010·International Journal of Pharmaceutics·Nor Amlizan Ramli, Tin Wui Wong
Mar 11, 2011·Biomacromolecules·S Van VlierbergheE Schacht
Sep 17, 2014·International Journal of Biological Macromolecules·M I Niyas AhamedT P Sastry
Sep 10, 1997·Analytica Chimica Acta·Qing ChangGovind Rao
Citations
Jun 28, 2016·Journal of Biomedical Materials Research. Part a·Xingyou HuLu Wang
Jun 1, 2017·Biotechnology Advances·Sheva NaahidiP Chen
Jan 27, 2018·Journal of Functional Biomaterials·Jensen DoucetDaniel Boyd
Apr 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cornelia VasileMihaela Baican
Dec 19, 2019·Frontiers in Bioengineering and Biotechnology·Jing SunYangzi Jiang
Jan 14, 2016·Materials·Ji Hye BaekMoon Suk Kim
Jun 13, 2018·Royal Society Open Science·S ChakrabortyV Muthuvijayan
Nov 14, 2017·Tissue Engineering and Regenerative Medicine·Sumi BangInsup Noh
Jul 7, 2018·Nanomaterials·Mihaela BalasAnca Dinischiotu
Apr 15, 2016·Macromolecular Bioscience·Ja Yong JangMoon Suk Kim
Jan 24, 2021·Carbohydrate Polymers·Allen ZenniferDhakshinamoorthy Sundaramurthi