PMID: 11900870Mar 20, 2002Paper

Synthesis and in vitro cytotoxic activity of pyrrolo[2,3-e]indole derivatives and a dihydro benzoindole analogue

European Journal of Medicinal Chemistry
Luis Chacón-García, Roberto Martínez

Abstract

The synthesis of pyrrolo[2,3-e]indole derivatives with the structural characteristics of DNA bis- and mono-intercalators are described. A dihydro benzoindol analogue was also synthesised to elucidate the major structural requirements for cytotoxic activity. A biological evaluation of the test compounds was carried out in six different tumoral cell lines. The factors that affect the cytotoxic activity appear to be the substituents on the phenyl group, the presence of an amide group capable of strong interactions such as hydrogen bonding and solubility.

References

Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·W Keller
Jun 5, 1991·Journal of the National Cancer Institute·A MonksA Vaigro-Wolff
Jul 4, 1990·Journal of the National Cancer Institute·P SkehanM R Boyd
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E M NelsonL F Liu
Dec 24, 1993·Science·E Culotta, D E Koshland
Feb 1, 1997·Bioorganic & Medicinal Chemistry·S E PattersonL Strekowski
Dec 19, 1996·Chemical Reviews·George A. Patani, Edmond J. LaVoie
Feb 1, 1961·Journal of Molecular Biology·L S LERMAN

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Citations

Jan 23, 2003·Bioorganic & Medicinal Chemistry·Maria T CoccoValentina Onnis
Dec 31, 2016·European Journal of Medicinal Chemistry·P V Sri RamyaAhmed Kamal
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Manar M ArafehRaid J Abdel-Jalil
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomas Horsten, Wim Dehaen

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