Synthesis and in vitro cytotoxic activity of compounds with pro-apoptotic potential.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Gisell Apicela SoaresElaine M de Souza-Fagundes

Abstract

In our search for new anticancer therapies, some compounds synthesized in our lab were selected and their potential cytotoxic activity was evaluated in vitro against two cancer cells lines including a solid tumor (UACC-62, melanoma) and a human lymphoma (JURKAT). Compounds showing cytotoxic activity were subjected to an apoptosis assay. Two compounds showed promising results.

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Citations

Jun 22, 2013·Journal of Chromatographic Science·Maria Betânia de FreitasCristina Duarte Vianna-Soares
Jul 30, 2019·Toxicology and Applied Pharmacology·Paulo Michel Pinheiro FerreiraRicardo José Alves

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Methods Mentioned

BETA
flow cytometry
NMR
column chromatography

Software Mentioned

Cell Quest Pro
FACSCalibur
Lysis

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