Synthesis and in vitro evaluation of gold(I) thiosemicarbazone complexes for antimalarial activity

Journal of Inorganic Biochemistry
Setshaba D KhanyeKelly Chibale

Abstract

The reaction of thiosemicarbazones (TSCs) with [Au(I)(THT)Cl], THT=tetrahydrothiophene, has been investigated. The resulting gold(I) complexes have been characterized by a range of spectroscopic techniques: NMR spectroscopy, mass spectrometry, microanalysis and infrared spectroscopy. The in vitro antimalarial data for gold(I) TSC complexes suggests that coordination of gold(I) to TSCs enhanced their efficacy against the malaria parasite Plasmodium falciparum and their inhibition of the parasite cysteine protease falcipain-2.

Citations

Oct 22, 2014·Journal of Enzyme Inhibition and Medicinal Chemistry·Akranth MarellaMohammad Mumtaz Alam
Feb 22, 2013·Chemical Reviews·Paloma F SalasChris Orvig
Jan 12, 2012·Inorganic Chemistry·Pedro I da S MaiaUlrich Abram
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Mar 1, 2017·Chemical Biology & Drug Design·Glaécia A N PereiraCláudio Nahum Alves
Mar 7, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Biljana Đ Glišić, Miloš I Djuran
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