Abstract
2,6-Dipeptidyl-anthraquinones are a promising class of nucleic acid-binding compounds that act as NC inhibitors in vitro. We designed, synthesized, and tested new series of 2,6-disubstituted-anthraquinones, which are able to bind viral nucleic acid substrates of NC. We demonstrate here that these novel derivatives interact preferentially with noncanonical structures of TAR and cTAR, stabilize their dynamics, and interfere with NC chaperone activity.
References
May 1, 1993·DNA and Cell Biology·E Saint-Jacques, C Séguin
Jul 1, 1997·Journal of Virology·J GuoJ G Levin
Nov 18, 2000·Journal of the National Cancer Institute·UNKNOWN International Collaboration on HIV and Cancer
Jan 3, 2004·Organic Letters·Malathy KrishnamurthyPeter A Beal
Aug 26, 2004·Journal of the American Chemical Society·Barry D Gooch, Peter A Beal
Oct 26, 2005·Chembiochem : a European Journal of Chemical Biology·Barry D GoochPeter A Beal
Mar 9, 2006·Nucleic Acids Research·Kevin B TurnerDaniele Fabris
Jul 29, 2006·Journal of the American Society for Mass Spectrometry·Kevin B TurnerDaniele Fabris
Jun 26, 2007·Advances in Pharmacology·Jean-Luc DarlixHugues de Rocquigny
Aug 11, 2007·Angewandte Chemie·Malathy KrishnamurthyPeter A Beal
Feb 19, 2008·Virus Research·James A Thomas, Robert J Gorelick
Feb 19, 2008·Virus Research·Vandana Purohit BasuRobert A Bambara
Aug 30, 2008·Journal of Medicinal Chemistry·Giuseppe ZagottoManlio Palumbo
Sep 16, 2008·Bioorganic & Medicinal Chemistry·Malathy KrishnamurthyPeter A Beal
Oct 24, 2008·Biopolymers·Kevin B TurnerDaniele Fabris
Jul 19, 2011·Journal of Molecular Biology·Jean-Luc DarlixYves Mély
Mar 15, 2013·Journal of Molecular Biology·Nathalie GoudreauSteve Titolo
Oct 26, 2013·Methods in Molecular Biology·Andrea Cimarelli, Jean-Luc Darlix
Apr 9, 2014·Nature Medicine·Elie Dolgin
Feb 5, 2015·Journal of Visualized Experiments : JoVE·Alice SosicBarbara Gatto
Mar 10, 2015·Current Topics in Microbiology and Immunology·Mattia MoriYves Mély
May 12, 2015·Organic & Biomolecular Chemistry·Jessica E Wynn, Webster L Santos
Citations
Dec 3, 2016·Biochemical Society Transactions·Jean-Luc DarlixYves Mély
Jun 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nafisa S SirazhetdinovaElvira E Shults
May 22, 2020·ACS Medicinal Chemistry Letters·Elia GambaBarbara Gatto
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alice SosicBarbara Gatto
Jun 22, 2021·European Journal of Medicinal Chemistry·Li ZhangYuning Song
May 22, 2020·ACS Medicinal Chemistry Letters·Stefano CiacoYves Mély
May 22, 2020·ACS Medicinal Chemistry Letters·Savina MalanconaMaurizio Botta
May 24, 2018·Bioconjugate Chemistry·Alice SosicBarbara Gatto