Synthesis and in Vitro Screening of New Series of 2,6-Dipeptidyl-anthraquinones: Influence of Side Chain Length on HIV-1 Nucleocapsid Inhibitors

Journal of Medicinal Chemistry
Francesco FrecenteseVincenzo Santagada

Abstract

2,6-Dipeptidyl-anthraquinones are a promising class of nucleic acid-binding compounds that act as NC inhibitors in vitro. We designed, synthesized, and tested new series of 2,6-disubstituted-anthraquinones, which are able to bind viral nucleic acid substrates of NC. We demonstrate here that these novel derivatives interact preferentially with noncanonical structures of TAR and cTAR, stabilize their dynamics, and interfere with NC chaperone activity.

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Citations

Jun 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nafisa S SirazhetdinovaElvira E Shults
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alice SosicBarbara Gatto
Jun 22, 2021·European Journal of Medicinal Chemistry·Li ZhangYuning Song
May 22, 2020·ACS Medicinal Chemistry Letters·Stefano CiacoYves Mély
May 22, 2020·ACS Medicinal Chemistry Letters·Savina MalanconaMaurizio Botta

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