PMID: 7512648Dec 1, 1993Paper

Synthesis and inverse emulsion polymerization of aminated acrylamidodextran

The Journal of Pharmacy and Pharmacology
C DaubresseE Schacht

Abstract

A chemically modified form of dextran was prepared, having a polymerizable moiety (acrylamide) and a reactive functional group (primary amine). Dextran was activated with 4-nitrophenyl-chloroformate (24 mol per polysaccharide, 9.8 mol per 100 glucose residues); 9.8% glucose residues were converted to aliphatic carbonates and 5.2% were converted to cyclic carbonates. The activated dextran was coupled with trityldiaminoethane (8 mol per 100 glucose residues), reactivated with 4-nitrophenylchloroformate, then coupled with acryloamidodiaminohexane (6.8 mol per 100 glucose residues). The trityl group was removed by hydrolysis with trifluoroacetic acid to yield the required aminated acryloamidodextran. The modified dextran was shown to be polymerizable by inverse emulsion polymerization. Submicron particles were successfully prepared, containing functional amine groups suitable for preparing drug conjugates or for modifying the surface properties of this biomaterial.

References

Mar 1, 1975·Analytical Biochemistry·S L Snyder, P Z Sobocinski
Aug 1, 1988·Journal of Pharmaceutical Sciences·A D McLeodC T Hung
Jul 1, 1980·Journal of Pharmaceutical Sciences·P EdmanI Sjöholm
Nov 1, 1984·Journal of Pharmaceutical Sciences·P ArturssonI Sjöholm

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Citations

Nov 15, 1996·Journal of Chromatography. B, Biomedical Applications·S AnastaseJ Jozefonvicz
Jan 31, 2007·Journal of Biomaterials Science. Polymer Edition·Tomohiro KonnoKazuhiko Ishihara

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