Synthesis and larvicidal activity against Culex pipiens pallens of new triazole derivatives of phrymarolin from Phryma leptostachya L

International Journal of Molecular Sciences
Ji-Wen ZhangWen-Jun Wu

Abstract

Twelve new triazole derivatives of Phrymarolin were prepared from Phrymarolin I and the structures of all the derivatives were fully characterized by (1)H-NMR, (13)C-NMR and MS spectral data analyses. Larvicidal activities against 4rd instar larvae of Culex pipiens pallens of these Phrymarolin analogues were assayed. Although the triazole derivatives of Phrymarolin showed certain larvicidal activity, they showed lower activity than Phrymarolin I. The typical non-natural groups triazole substituents reduced the larvicidal activity of Phrymarolin derivatives.

Citations

May 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yankai LiZhaonong Hu

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Methods Mentioned

BETA
NMR
column chromatography

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