Synthesis and maturation of type I and type III collagens in endometrial adenocarcinoma

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Tommi JussilaFrej Stenbäck

Abstract

The structure and distribution of type I and type III collagens in the extracellular matrix of malignant endometrium was evaluated for their roles in the development and progression of this neoplasm. Collagen synthesis and deposition in endometrial adenocarcinomas was determined by immunohistochemical analysis of type I and type III procollagen and verified by computer-assisted morphometry and in situ hybridization. In the stroma of well-differentiated adenocarcinomas increased intracellular collagen synthesis was observed in fibroblastic cells as well as increased extracellular formation of newly synthesized type I and type III procollagen. Collagen maturation was also rapid. In moderately differentiated tumors, destruction and dissolution occurred around invading islets, concomitantly with decreased deposits of both collagens, despite increases in corresponding mRNAs. In poorly differentiated neoplasms, solid epithelial islets coexisted with sparse and distinctly collagen-positive stroma. Poorly differentiated neoplasms also contained tumor cells exhibiting intracellular collagen staining as well as in situ hybridization signals. In highly malignant papillary adenocarcinomas, the tumor cells induced distinctly increased colla...Continue Reading

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Citations

Mar 12, 2009·Applied Immunohistochemistry & Molecular Morphology : AIMM·Vera C AraújoNey S Araújo
Nov 27, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nan ChenXiaobei Dong
Aug 19, 2007·Cancer Genetics and Cytogenetics·Sandra KarlssonKarin Klinga Levan
Feb 1, 2009·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·Luciano Kay, Philip Shapira
Apr 22, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·D J LeemingM A Karsdal

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