Synthesis and multi-spectroscopic study on DNA-binding, cleavage and biological properties of M(II) complexes based on N2 O2 donor Schiff base ligand

Luminescence : the Journal of Biological and Chemical Luminescence
V Violet Dhayabaran, T Daniel Prakash

Abstract

A novel Schiff base, (S,Z)-4-(methylthio)-2-((3-oxo-2,3-dihydro-1H-inden-1-ylidene)amino)butanoic acid (L) and four M(II) complexes (where M = Co, Cu, Ni and Zn) were synthesized and characterized. The DNA-binding characteristics of the complexes were investigated using various spectroscopic methods and viscosity measurements. Analysis of the results suggests that all the complexes bind to calf thymus DNA via intercalation. Among the four, Cu(II) complex was found to promote the photocleavage of plasmid DNA pBR322 under irradiation at 365 nm. These complexes also exhibit good antioxidant activities against 2,2-diphenyl-1-picrylhydrazyl radical. In vitro antibacterial and antifungal assay indicates that these complexes are good antimicrobial agents.

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Citations

Jan 4, 2019·Luminescence : the Journal of Biological and Chemical Luminescence·Khyati P ThakorMohan N Patel
Jul 28, 2021·Chemical Society Reviews·Yan LinGilles Gasser

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