Synthesis and oxidant properties of novel (5-bromobenzofuran-2-yl)(3-methyl-3-mesitylcyclobutyl)ketonethiosemicarbazone

European Journal of Medicinal Chemistry
F KaratasSüleyman Servi

Abstract

The reaction of 5-bromosalicylaldehyde with 1-mesityl-1-methyl-3-(2-chloro-1-oxoethyl)cyclobutane (1) and potassium carbonate was used to prepare (5-bromobenzofuran-2-yl)(3-methyl-3-mesitylcyclobutyl)methanone (2) for the starting reagent purposes. (5-Bromobenzofuran-2-yl)(3-methyl-3-mesitylcyclobutyl)ketonethiosemicarbazone (3) was synthesized from the reaction of the compound (2) with thiosemicarbazide. In the present study, it was aimed to examine the influence of synthetic (5-bromobenzofuran-2-yl)(3-methyl-3-mesityl cyclobutyl)ketonethiosemicarbazone on levels of vitamins (A, E, C), selenium and malondialdehyde in rats. A total of 42 rats were used and the animals were divided into two groups in the study. Only a subcutaneous injection of 250 microl of 75% ethanol was given to the control group every other day. A subcutaneous injection of this compound (25 mg kg-1, dissolved in 250 microl of 75% ethanol) was administered to the other group of rats. After the application of (5-bromobenzofuran-2-yl)(3-methyl-3-mesitylcyclobutyl)ketonethiosemicarbazone for 20 days, the serum vitamins (A, E, C) and malondialdehyde levels were determined with high performance liquid chromatography, the serum selenium level was determined by usin...Continue Reading

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Citations

Sep 11, 2008·Biological Trace Element Research·Fikret KaratasSinan Saydam
Sep 17, 2009·Biological Trace Element Research·Fikret KaratasHaki Kara
Jan 26, 2013·Chemical Reviews·Bagher Eftekhari-SisAli Akbari
Jul 8, 2015·European Journal of Medicinal Chemistry·Wageeh A YehyeMarzieh Yaeghoobi
Dec 9, 2014·European Journal of Medicinal Chemistry·Hena Khanam, Shamsuzzaman
Oct 10, 2014·European Journal of Medicinal Chemistry·Azhar AriffinFarkaad A Kadir
May 31, 2011·Life Sciences·Rômulo Pillon BarcelosNilda Vargas Barbosa
Mar 18, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Anand K HalveKiran Tiwari
May 12, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Haki KaraAziz Karaoglu

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