PMID: 7741775Mar 1, 1995

Synthesis and pharmacological characterization of some benzazepinone derivatives

Arzneimittel-Forschung
Roberta BudriesiPiero Valenti

Abstract

A series of some benzazepinone derivatives were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonist properties. For the compounds bearing well-known alpha-blocking fragments, the antagonist potency at postsynaptic alpha-adrenoceptors was assessed. The new compounds were less effective as bradycardic agents and calcium antagonists but show remarkable negative inotropic activity.

Related Concepts

Adrenergic alpha-Antagonists
Descending Aorta
Benzazepines
Calcium Channel Blockers
Cardiotonic Agents
Cavia porcellus
Right Atrial Structure
Pulse Rate
Inotropism
Muscle, Smooth, Vascular

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