Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity.

Journal of Medicinal Chemistry
Sheela K ChellappanAlan P Kozikowski

Abstract

We report the synthesis and pharmacological properties of several cytisine derivatives. Among them, two 10-substituted derivatives showed much higher selectivities for the alpha4beta2 nAChR subtype in binding assays than cytisine. The 9-vinyl derivative was found to have a very similar agonist activity profile to that of cytisine.

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Citations

Sep 21, 2013·European Journal of Medicinal Chemistry·Lucie MaingotRebecca Deprez-Poulain
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Jan 6, 2022·Journal of Asian Natural Products Research·Peng ZhangXiao-Jiang Hao

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