Synthesis and pharmacological evaluation of condensed heterocyclic 6-substituted 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives of isoniazid

Bioorganic & Medicinal Chemistry Letters
Sadaf J GilaniNadeem Siddiqui

Abstract

The significance of this study was to prepare various isoniazid derivatives by introducing the isoniazid core into several molecules to explore the possibilities of some altered biological activities. Series of 6-substituted-1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole (3a-g) and 1,3,4-oxadiazole (4a-g and 5) derivatives of isoniazid were synthesized in satisfactory yield and pharmacologically evaluated for their anti-inflammatory, analgesic, ulcerogenic, and lipid peroxidation activities by known experimental models.

Citations

Jan 24, 2014·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Ali AlmasiradAbbas Shafiee
May 15, 2013·Expert Opinion on Therapeutic Patents·Afshin Zarghi, Zahra Hajimahdi
Aug 29, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cledualdo Soares de OliveiraPetrônio Filgueiras de Athayde-Filho
Oct 12, 2010·The Journal of Toxicological Sciences·Nagaraja HaleagraharaAnupama Kulur
Jan 17, 2012·Organic & Biomolecular Chemistry·Manishkumar B PatelShobhana K Menon

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