PMID: 41927Oct 1, 1979

Synthesis and pharmacology of potential beta-blockers

Journal of Pharmaceutical Sciences
J P O'DonnellR J Gorczynski


Several 1-(4-substituted phenoxyl)-2-hydroxy-3-isopropylaminopropanes and 1-(4-substituted phenoxy)-2-hydroxy-3-[3,4-dimethoxyphenethyl]aminopropanes were synthesized for possible beta-adrenergic receptor blockage. The compounds were synthesized by reaction of the 4-substituted phenol with epichlorohydrin and subsequent opening of the resulting epoxide with either N-isopropylamine or N-3,4-dimethoxyphenethylamine. Preliminary biological testing indicated a decrease in the beta-blocking potency and the duration of action.


Jun 5, 1972·JAMA : the Journal of the American Medical Association·S Barrett


Dec 23, 1999·Medicinal Research Reviews·N Bodor, P Buchwald

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