Synthesis and physicochemical characterization of amphiphilic triblock copolymer brush containing pH-sensitive linkage for oral drug delivery

Langmuir : the ACS Journal of Surfaces and Colloids
You Qiang YangLi Juan Zhang

Abstract

A novel and well-defined pH-sensitive amphiphilic triblock copolymer brush poly(lactide)-b-poly(methacrylic acid)-b-poly(poly(ethylene glycol) methyl ether monomethacrylate) (PLA-b-PMAA-b-PPEGMA) and its self-assembled micelles were developed for oral administration of hydrophobic drugs. The copolymer and its precursors were synthesized by the combination of activators regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP) and ring-opening polymerization (ROP) techniques. The molecular structures and characteristics were confirmed by GPC, (1)H NMR, and FT-IR. The critical micelle concentration (CMC) values of PLA-b-PMAA-b-PPEGMA in aqueous medium varied from 1.4 to 2.6 mg/L, and the partition equilibrium constant (K(v)) of pyrene in micellar solutions ranged from 2.873 × 10(5) to 3.312 × 10(5). The average sizes of the self-assembled blank and drug-loaded micelles were 140-250 nm determined by DLS in aqueous solution. The morphology of the micelles was found to be spherical by SEM. Nifedipine (NFD), a poorly water-soluble drug, was selected as the model drug and wrapped into the core of micelles via dialysis method. The in vitro release behavior of NFD from the micelles was pH-dependent. In simulated...Continue Reading

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Citations

Aug 2, 2013·The Journal of Chemical Physics·Leonidas N GergidisCostas Vlahos
Sep 18, 2014·Expert Opinion on Drug Delivery·Susana Mn SimõesCarmen Alvarez-Lorenzo
Dec 15, 2015·International Journal of Pharmaceutics·Thisirak WoraphatphadungPraneet Opanasopit
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Nov 9, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Leonidas N GergidisCostas Vlahos
Jun 24, 2016·Journal of Biomaterials Applications·Huijuan ZhangZhenzhong Zhang
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Jun 18, 2020·Pharmaceuticals·Pataranapa NimtrakulClive A Prestidge
Aug 31, 2018·Frontiers in Bioengineering and Biotechnology·N Vijayakameswara RaoJae Hyung Park
Jun 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Nidhi RavalRakesh K Tekade
Jul 19, 2021·Advances in Colloid and Interface Science·Didier Gigmes, Thomas Trimaille

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