Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens

Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents
Bini MathewRobert C Reynolds

Abstract

As part of an ongoing program to study the anticancer activity of non-steroidal anti-inflammatory drugs (NSAIDs) through generating diversity libraries of multiple NSAID scaffolds, we synthesized a series of NSAID amide derivatives and screened these sets against three cancer cell lines (prostate, colon and breast) and Wnt/β-catenin signaling. The evaluated amide analog libraries show significant anticancer activity/cell proliferation inhibition, and specific members of the sets show inhibition of Wnt/β-catenin signaling.

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Citations

Apr 20, 2018·Future Medicinal Chemistry·Bini MathewRobert C Reynolds
May 20, 2018·Bioorganic & Medicinal Chemistry Letters·Bini MathewRobert C Reynolds
Jan 22, 2022·The Journal of Organic Chemistry· SonamAnil Kumar

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